Understanding FLT3m+ AML

What Is AML?

Acute myeloid leukemia, or AML, can be an overwhelming diagnosis. When you find out that you or someone you love has AML, it can be hard to know where to begin. The first step is to learn more about the disease.

Bone Marrow With AML

Bone Marrow with AML

AML is a type of blood cancer that starts in the bone marrow. The bone marrow is where red and white blood cells are made, as well as platelets. When someone has AML, their bone marrow makes abnormal blood cells, called blasts or leukemia cells. These leukemia cells can grow and divide quickly.

Approximately 20,000 people are diagnosed with AML every year.

How Common Is AML?

AML is one of the most common types of leukemia in adults. Around 20,000 people are diagnosed every year.* AML typically affects older adults, but it can also appear in younger people.

*Based on estimate of new cases in 2020.

What Is FLT3 Mutation-Positive (FLT3m+) AML?

The most common type of mutation in AML occurs in the FLT3 gene. Mutations in the FLT3 gene cause leukemia cells to grow and multiply. This leaves less room for healthy blood cells to develop.

1 out of 3 people.

with AML may have a FLT3 mutation

FLT3 mutations can change throughout treatment. This means that even if you did not have a FLT3 mutation at diagnosis, you may develop one when you relapse. The presence of FLT3 mutations can also affect how your AML progresses.

What Does It Mean to Relapse or Be Refractory to Treatment?

Relapse is when AML comes back after a period of improvement.

Refractory to treatment means the AML has not improved after previous treatment(s).