How Does XOSPATA Work?

Man in front of a lamp and table.

XOSPATA Is a Targeted Therapy

XOSPATA works differently than traditional chemotherapy. Traditional chemotherapy works by killing fast-growing cells, which can include cancer cells and other types of cells. Targeted therapies are designed to target certain features of cancer cells, like mutations. Other cells in the body may still be affected during treatment, but this type of therapy is designed with a specific target in mind.

When you have FLT3m+ AML, the number of leukemia cells increases in the bone marrow, leaving less room for healthy cells to grow. XOSPATA targets the FLT3 mutation, which may keep AML cells from growing in the bone marrow. With fewer leukemia cells, the bone marrow may have more room for healthy blood cells.

Bone marrow icon.

Artist rendition. This animation is intended to help illustrate how XOSPATA was shown to work in laboratory studies. Individual results may vary.

XOSPATA is the only FDA-approved targeted therapy for people with FLT3m+ AML when the disease has come back or has not improved after previous treatment(s).

Select Safety Information

XOSPATA may cause serious side effects including:

  • Posterior Reversible Encephalopathy Syndrome (PRES). If you take XOSPATA, you may be at risk of developing a condition involving the brain called PRES. Tell your healthcare provider right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision, or other visual problems. Your healthcare provider will do a test to check for PRES. Your healthcare provider will stop XOSPATA if you develop PRES.