The Facts About FLT3m+ AML

What Is Acute Myeloid Leukemia (AML)?

Acute myeloid leukemia, or AML, is a type of blood cancer that starts in the bone marrow. The bone marrow is where blood cells are made.

AML affects how blood cells develop in the bone marrow. AML is caused by changes to the genes in some developing blood cells. These changes are called mutations, which can cause the blood cells to become leukemia cells.

 
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What Is FLT3 Mutation-Positive (FLT3m+) AML?

One of the more common types of mutations in AML occurs in the FLT3 gene. The FLT3 gene is one of many genes found in healthy blood cells that help them develop. In FLT3m+ AML, mutations in the FLT3 gene cause leukemia cells to grow and multiply, leaving less room for healthy blood cells to develop.


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How Do Doctors Know if AML Is FLT3m+?

Doctors use a bone marrow or blood test of a person with leukemia to find out if FLT3 mutations are present. FLT3 mutations may be seen at diagnosis, or over time. Your bone marrow or blood test showed you have a FLT3 mutation, meaning you tested positive for the mutation. Because you've tested positive, your doctor may consider a medicine that targets FLT3.


What Does It Mean to Relapse or Be Refractory to Treatment?

You may have been on a treatment for AML, but have relapsed or were refractory to treatment.

  • Relapse is when AML has come back after a period of improvement.
  • Refractory to treatment means the AML did not respond to initial treatments.
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Who should not take XOSPATA?

Do not take XOSPATA if you are allergic to gilteritinib or any of the ingredients in XOSPATA.